Tumor Invasion: Role of Growth Factor-Induced Cell Motility

摘要: Cancer progression to the invasive and metastatic stage represents most formidable barrier successful treatment. To develop rational therapies, we must determine molecular bases of these transitions. Cell motility is one defining characteristics tumors, enabling tumors migrate into adjacent tissues or transmigrate limiting basement membranes extracellular matrices. Invasive tumor cells have been demonstrated present dysregulated cell in response signals from growth factors cytokines. Recent findings suggest that this factor receptor-mediated common aberrations leading invasiveness a cellular behavior distinct from-adhesion-related haptokinetic haptotactic migration. This review focuses on emerging understanding biochemical biophysical foundations factor-induced invasiveness, implications for development targeted agents, with particular emphasis signaling epidermal (EGF) hepatocyte (HGF) receptors, as often associated invasion. The nascent models highlight roles various intracellular pathways including phospholipase C-gamma (PLC gamma), phosphatidylinositol (PI)3'-kinase, mitogen-activated protein (MAP) kinase, actin cytoskeleton-related events. Development novel agents against invasion will require not only detailed appreciation regulatory elements but also paradigm shift our approach assessment cancer therapy.