Decreased expression of tissue inhibitor of metalloproteinases in metastatic tumor cells leading to increased levels of collagenase activity.

摘要: We have examined the expression of murine tissue inhibitor metalloproteinases (TIMP) in nonmetastatic and metastatic cell lines derived from SP1 mammary adenocarcinoma cells. observed decreased levels TIMP mRNA activity cells as compared to their equivalents absence fetal bovine serum. Lower correlated transcription gene. Net collagenase was higher cells, but secreted similar total (mainly type IV). This suggests that gene results increased net malignant