Matrix metalloproteinases and their inhibitors in tumor invasion and metastasis

摘要: The recent progress in matrix metalloproteinases (MMPs) research has opened up many cellular targets a variety of diseases. We have discussed some the interesting and newly described roles MMPs modulating metastatic phenotype malignancies. This information suggests more specific exclusive role as important regulators tumor cell invasion metastasis. A great deal room exists for redefining our current understanding system; we understand about how act, better will pathobiology Research regulation potential use therapeutic interventions metastasis continues to expand. future therapy involving inhibitors part armamentarium against human neoplasm should be viewed with cautious optimism. approach is beginning find place tumors, but perhaps few exceptions still considered experimental. area now needs biological knowledge imagination on investigators make achievements possible.