The impact of metabolites derived from the gut microbiota on immune regulation and diseases.

作者: Hiroshi Ohno

DOI: 10.1093/INTIMM/DXAA041

关键词: DysbiosisGut floraBiologyEpigenomicsMetabolomeCell biologyMetabolomicsEpigeneticsMicrobiomeImmune system

摘要: … enhances colonic regulatory T-cell differentiation through its … secondary bile acids could also induce the differentiation of … pT reg differentiation, both in in vitro T reg induction culture …

参考文章(53)
Ethan M. Shevach, Biological Functions of Regulatory T Cells Advances in Immunology. ,vol. 112, pp. 137- 176 ,(2011) , 10.1016/B978-0-12-387827-4.00004-8
Hyang-Mi Lee, Jhoanne Lynne Bautista, Chyi-Song Hsieh, Thymic and Peripheral Differentiation of Regulatory T Cells Advances in Immunology. ,vol. 112, pp. 25- 71 ,(2011) , 10.1016/B978-0-12-387827-4.00002-4
Shinji Fukuda, Hidehiro Toh, Todd D. Taylor, Hiroshi Ohno, Masahira Hattori, Acetate-producing bifidobacteria protect the host from enteropathogenic infection via carbohydrate transporters Gut Microbes. ,vol. 3, pp. 449- 454 ,(2012) , 10.4161/GMIC.21214
Koji Atarashi, Yoshinori Umesaki, Kenya Honda, Microbiotal influence on T cell subset development. Seminars in Immunology. ,vol. 23, pp. 146- 153 ,(2011) , 10.1016/J.SMIM.2011.01.010
Nagendra Singh, Ashish Gurav, Sathish Sivaprakasam, Evan Brady, Ravi Padia, Huidong Shi, Muthusamy Thangaraju, Puttur D. Prasad, Santhakumar Manicassamy, David H. Munn, Jeffrey R. Lee, Stefan Offermanns, Vadivel Ganapathy, Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis Immunity. ,vol. 40, pp. 128- 139 ,(2014) , 10.1016/J.IMMUNI.2013.12.007
John R Ussher, Gary D Lopaschuk, Arduino Arduini, None, Gut microbiota metabolism of l-carnitine and cardiovascular risk Atherosclerosis. ,vol. 231, pp. 456- 461 ,(2013) , 10.1016/J.ATHEROSCLEROSIS.2013.10.013
Abul K Abbas, Christophe Benoist, Jeffrey A Bluestone, Daniel J Campbell, Sankar Ghosh, Shohei Hori, Shuiping Jiang, Vijay K Kuchroo, Diane Mathis, Maria Grazia Roncarolo, Alexander Rudensky, Shimon Sakaguchi, Ethan M Shevach, Dario AA Vignali, Steve F Ziegler, None, Regulatory T cells: recommendations to simplify the nomenclature Nature Immunology. ,vol. 14, pp. 307- 308 ,(2013) , 10.1038/NI.2554
Jennifer M. Ritchie, Animal Models of Enterohemorrhagic Escherichia coli Infection Microbiology spectrum. ,vol. 2, pp. 175- 195 ,(2014) , 10.1128/MICROBIOLSPEC.EHEC-0022-2013
Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Takaho A. Endo, Gaku Nakato, Daisuke Takahashi, Yumiko Nakanishi, Chikako Uetake, Keiko Kato, Tamotsu Kato, Masumi Takahashi, Noriko N. Fukuda, Shinnosuke Murakami, Eiji Miyauchi, Shingo Hino, Koji Atarashi, Satoshi Onawa, Yumiko Fujimura, Trevor Lockett, Julie M. Clarke, David L. Topping, Masaru Tomita, Shohei Hori, Osamu Ohara, Tatsuya Morita, Haruhiko Koseki, Jun Kikuchi, Kenya Honda, Koji Hase, Hiroshi Ohno, Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells Nature. ,vol. 504, pp. 446- 450 ,(2013) , 10.1038/NATURE12721