Modulation of the enterohemorrhagic E. coli virulence program through the human gastrointestinal tract

作者: Debora Barnett Foster

DOI: 10.4161/VIRU.24318

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摘要: Enteric pathogens must not only survive passage through the gastrointestinal tract but also coordinate expression of virulence determinants in response to localized microenvironments with host. Enterohemorrhagic Escherichia coli (EHEC), a serious food and waterborne human pathogen, is well equipped an arsenal molecular factors that allows it successfully colonize large intestine. This review will explore how EHEC responds various environmental cues associated particular within host employs these modulate factor expression, view developing conceptual framework for understanding modulation EHEC’s program In vitro studies offer significant insights into role individual vivo using animal models as data from natural infections ultimately provide more comprehensive pictur...

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