Medication improves balance and complex gait performance in Parkinson disease.

作者: Marie E. McNeely , Ryan P. Duncan , Gammon M. Earhart

DOI: 10.1016/J.GAITPOST.2012.02.009

关键词: Physical medicine and rehabilitationLead (electronics)Severity of illnessPsychologyPhysical therapyPostural BalanceSTRIDECadenceGait (human)Berg Balance ScaleBalance (ability)

摘要: Gait and balance impairments in people with Parkinson disease (PD) may lead to falls serious injuries. Therefore, it is critical improve our understanding of the nature these impairments, including how they respond prescribed anti-Parkinson medication. This particularly important for complex gait tasks that be associated falls. We evaluated motor function, functional balance, performance during various 22 PD OFF ON medication (PD OFF, ON) 20 healthy older adults. Although MDS-UPDRS-III score, Berg Balance Scale, Mini-Balance Evaluations Systems test, Timed-Up-and-Go improved medication, persisted all measures on compared controls. Dual task did not required more time than velocity stride length similarly across forward, fast, backward, dual backward tasks. Cadence change nor differ between Velocity were reduced reductions fast cadence-mediated, while length-mediated. Our results suggest improves regardless complexity. Remaining highlight need examine additional therapeutic options individuals reduce risk

参考文章(32)
Marie E. McNeely, Gammon M. Earhart, The effects of medication on turning in people with Parkinson disease with and without freezing of gait. Journal of Parkinson's disease. ,vol. 1, pp. 259- 270 ,(2011) , 10.3233/JPD-2011-11030
Jack I. Williams, Sharon Wood-Dauphinee, Brian E. Maki, Katherine Berg, Measuring balance in the elderly: validation of an instrument Canadian Journal of Public Health-revue Canadienne De Sante Publique. ,vol. 83, ,(1992)
Victor Jupp, Roger Sapsford, Data Collection and Analysis ,(2006)
R. Grasso, L. Bianchi, F. Lacquaniti, Motor Patterns for Human Gait: Backward Versus Forward Locomotion Journal of Neurophysiology. ,vol. 80, pp. 1868- 1885 ,(1998) , 10.1152/JN.1998.80.4.1868
F. B. Horak, J. Frank, J. Nutt, Effects of dopamine on postural control in parkinsonian subjects: scaling, set, and tone Journal of Neurophysiology. ,vol. 75, pp. 2380- 2396 ,(1996) , 10.1152/JN.1996.75.6.2380
S. Colnat-Coulbois, G.C. Gauchard, L. Maillard, G. Barroche, H. Vespignani, J. Auque, P.P. Perrin, Management of postural sensory conflict and dynamic balance control in late-stage Parkinson's disease Neuroscience. ,vol. 193, pp. 363- 369 ,(2011) , 10.1016/J.NEUROSCIENCE.2011.04.043
B.R. Bloem, Postural instability in Parkinson's disease. Clinical Neurology and Neurosurgery. ,vol. 94, pp. 41- 45 ,(1992) , 10.1016/0303-8467(92)90018-X
Martina Mancini, Laura Rocchi, Fay B. Horak, Lorenzo Chiari, Effects of Parkinson’s disease and levodopa on functional limits of stability Clinical Biomechanics. ,vol. 23, pp. 450- 458 ,(2008) , 10.1016/J.CLINBIOMECH.2007.11.007
Nicolaas I. Bohnen, Rakié Cham, Postural Control, Gait, and Dopamine Functions in Parkinsonian Movement Disorders Clinics in Geriatric Medicine. ,vol. 22, pp. 797- 812 ,(2006) , 10.1016/J.CGER.2006.06.009
Sue Lord, Katherine Baker, Alice Nieuwboer, David Burn, Lynn Rochester, Gait variability in Parkinson's disease: an indicator of non-dopaminergic contributors to gait dysfunction? Journal of Neurology. ,vol. 258, pp. 566- 572 ,(2011) , 10.1007/S00415-010-5789-8