Sequential treatment strategy for malignant pleural effusion in non-small cell lung cancer with the activated epithelial grow factor receptor mutation.
作者： Jian-Bo Lin , Fan-Cai Lai , Xu Li , Yuan-Rong Tu , Min Lin
DOI: 10.1080/1061186X.2016.1200590
关键词: Toxicity 、 Internal medicine 、 Chemotherapy 、 Gefitinib 、 Surgery 、 Epidermal growth factor receptor 、 Lung cancer 、 Pleurodesis 、 Malignant pleural effusion 、 Targeted therapy 、 Oncology 、 Medicine
摘要: AbstractWith the advent of molecularly targeted therapy, it is necessary to reconsider strategy for malignant pleural effusion in non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. The aim this study was evaluate efficacy a two-line sequential treatment patient subgroup. First-line gefitinib (250 mg/day) until disease progression. Second-line thoracoscopic talc pleurodesis followed by chemotherapy. Primary endpoints were overall response and progression-free survival rates after first-line treatment, rate first- second-line treatment. Secondary success toxicity. Among 76 patients enrolled, 61 (80%) female median age 62 years. 92.1% 15 months. ta...
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