DNA nanomachines and nanostructures involving quadruplexes
作者： Patrizia Alberti , Anne Bourdoncle , Barbara Sacc? , Laurent Lacroix , Jean-Louis Mergny
DOI: 10.1039/B605739J
关键词: Nanotechnology 、 Cytosine 、 Biophysics 、 Molecular machine 、 Molecular recognition 、 DNA 、 RNA 、 Chemistry 、 Guanine 、 Nanostructure
摘要: DNA is an attractive component for molecular recognition, because of its self-assembly properties. Its three-dimensional structure can differ markedly from the classical double helix. For example, or RNA strands carrying guanine cytosine stretches associate into four-stranded structures called G-quadruplexes i-DNA, respectively. Since 2002, several groups have described nanomachines that take advantage this structural polymorphism. We first introduce unusual are involved in these devices (i.e., i-DNA and G-quadruplexes) then describe opening closing steps allow cycling. A quadruplex–duplex machine presented detail, together with rules govern formation, opening/closing kinetics various technical physico-chemical parameters play a role efficiency device. Finally, we review few examples nanostructures involve quadruplexes.
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