Cardiovascular effects of leptin
作者： Gary Sweeney
DOI: 10.1038/NRCARDIO.2009.224
关键词: Cardiovascular Physiological Phenomena 、 Paracrine signalling 、 Internal medicine 、 Inflammation 、 Leptin 、 Endothelial dysfunction 、 Obesity paradox 、 Adipose tissue 、 Medicine 、 Endocrinology 、 Endothelium
摘要: A wealth of investigations, ranging from clinical and animal model studies to in vitro analyses, have generated great interest the cardiovascular effects leptin. Accordingly, many examined contribution leptin cardiac remodeling heart failure whether on metabolism, apoptosis, extracellular matrix remodeling, hypertrophy could explain so-called obesity paradox. Furthermore, hyperleptinemia often been associated with hypertension, regulation sympathetic tone or direct contributors such as atherosclerosis, endothelial dysfunction, thrombosis documented. Unfortunately, translating basic research vitro, models, human physiology has proven difficult. The degree resistance is one intriguing issue that must be resolved. importance autocrine paracrine derived perivascular adipose tissue further studied. Carefully planned executed conclusively establish distinct system normal diseased states will essential harness any therapeutic potential leptin's effects.
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calis.edu.cn 参考文章(109)
Seth S. Martin, Atif Qasim, Muredach P. Reilly, Leptin Resistance Journal of the American College of Cardiology. ,vol. 52, pp. 1201- 1210 ,(2008) , 10.1016/J.JACC.2008.05.060
William G. Haynes, Role of leptin in obesity-related hypertension. Experimental Physiology. ,vol. 90, pp. 683- 688 ,(2005) , 10.1113/EXPPHYSIOL.2005.031237
Giovanni Vulpetti, Les Johnson, Gregory L Matloff, Giovanni Vulpetti, Les Johnson, Gregory L Matloff, Progress to Date Solar Sails. pp. 143- 153 ,(2015) , 10.1007/978-1-4939-0941-4_13
Seika Kamohara, Rémy Burcelin, Jeffrey L. Halaas, Jeffrey M. Friedman, Maureen J. Charron, Acute stimulation of glucose metabolism in mice by leptin treatment. Nature. ,vol. 389, pp. 374- 377 ,(1997) , 10.1038/38717
A. K. M. Tarikuz Zaman, Satoshi Fujii, Hirotumi Sawa, Daisuke Goto, Naoki Ishimori, Keiko Watano, Takeaki Kaneko, Tomoo Furumoto, Taeko Sugawara, Ichiro Sakuma, Akira Kitabatake, Burton E. Sobel, Angiotensin-converting enzyme inhibition attenuates hypofibrinolysis and reduces cardiac perivascular fibrosis in genetically obese diabetic mice. Circulation. ,vol. 103, pp. 3123- 3128 ,(2001) , 10.1161/01.CIR.103.25.3123
Marcelo L. G. Correia, Kamal Rahmouni, Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome. Diabetes, Obesity and Metabolism. ,vol. 8, pp. 603- 610 ,(2006) , 10.1111/J.1463-1326.2005.00562.X
Jerzy Beltowski, Leptin and atherosclerosis Atherosclerosis. ,vol. 189, pp. 47- 60 ,(2006) , 10.1016/J.ATHEROSCLEROSIS.2006.03.003
Diamantis Konstantinidis, Konstantinos Paletas, George Koliakos, Martha Kaloyianni, Signaling components involved in leptin-induced amplification of the atherosclerosis-related properties of human monocytes. Journal of Vascular Research. ,vol. 46, pp. 199- 208 ,(2009) , 10.1159/000161234
Claudia Dellas, Katrin Schäfer, Ilonka Rohm, Mareike Lankeit, Thomas Ellrott, Vivien Faustin, Joachim Riggert, Gerd Hasenfuss, Stavros Konstantinides, Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity. Thrombosis and Haemostasis. ,vol. 100, pp. 1123- 1129 ,(2008) , 10.1160/TH08-05-0314
Naftali Stern, Yonit Marcus, Perivascular fat: innocent bystander or active player in vascular disease? Journal of The Cardiometabolic Syndrome. ,vol. 1, pp. 115- 120 ,(2006) , 10.1111/J.1559-4564.2006.05510.X