Acute stimulation of glucose metabolism in mice by leptin treatment.

摘要: Leptin is an adipocyte hormone that functions as afferent signal in a negative feedback loop regulating body weight1,2,3,4, and acts by interacting with receptor the hypothalamus other tissues5,6. treatment has potent effects on lipid metabolism, leads to large, specific reduction of adipose tissue mass after several days1,4. Here we show leptin also acutely increase glucose although studies leptin's effect metabolism have typically been confounded weight-reducing actions treatment, which itself could affect homoeostasis1,2,3. We demonstrated acute vivo intravenous intracerebroventricular administrations metabolism. A five-hour infusion into wild-type mice increased turnover uptake, but decreased hepatic glycogen content. The plasma levels insulin did not change. Similar were observed both leptin, suggesting are mediated central nervous system (CNS). These data indicate induces complex metabolic response well This unique suggests new efferent signals emanate from CNS treatment.