The Role of Cell Cycle Regulatory Protein, Cyclin D1, in the Progression of Thyroid Cancer

摘要: Cell cycle progression is facilitated by cyclin-dependent kinases that are activated cyclins including cyclin D1 and inactivated kinase inhibitors (CDKIs) such as p27. Our previous studies have demonstrated decreased p27 expression in both papillary more aggressive carcinomas of the thyroid compared to adenoma almost similar level between carcinoma. These results indicate CDKIs may an important role carcinogenesis they probably a limited malignant cancer. The carcinoma has yet be established. We studied immunohistochemistry 34 cases conventional (CPC), 10 minimally invasive follicular (MIFC), 32 (ATC), which included 11 tall cell variants, one columnar variant carcinoma, seven insular carcinomas, 13 anaplastic carcinomas. Cyclin staining was classified score 0, negative; 1+, less than 25%; 2+, 25 50%; 3+, 50% tumor cells positive. Kruskal-Wallis one-way ANOVA Wilcoxon Rank Sum/Mann-Whitney U Test used assess difference study groups. Twenty-eight out CPCs were positive, 24 (70%) 3 (9%) (3%) 3+ Seven MIFCs five (71%) remaining two (29%) 2+ On other hand, 28 ATCs showed immunostaining. Of these, three (13%) 20 (63%) This demonstrates significant overexpression ATC CPC (P < .001) MIFC .005), suggesting play prognostic significance