Early life innate immune signatures of persistent food allergy

摘要: Background Food allergy naturally resolves in a proportion of food-allergic children without intervention; however the underlying mechanisms governing persistence or resolution food childhood are not understood. Objectives This study aimed to define innate immune profiles associated with egg at age 1 year, determine phenotypic changes that occur development natural tolerance childhood, and explore relationship between early life function serum vitamin D. Methods used longitudinally collected PBMC samples from population-based cohort challenge-confirmed egg-allergic infants either persistent transient outcomes phenotype quantify functional response clinical phenotypes allergy. Results We show exhibit unique signature, characterized by increased numbers circulating monocytes dendritic cells produce more inflammatory cytokines both baseline following endotoxin exposure when compared Follow-up analysis revealed this signature continues into those D levels correlate observed who developed egg. Conclusions Early dysfunction may represent key immunological driver predictor childhood. Serum play an immune-modulatory role tolerance.