25-hydroxyvitamin D3 status is associated with developing adaptive and innate immune responses in the first 6 months of life

摘要: SummaryBackground Vitamin D (25[OH]D3) status in early life has been linked to the risk of allergic disease multiple observational studies. While immunomodulating properties are well recognized, there few longitudinal studies 25(OH)D3 status, immune function and infants. Objective To investigate levels at birth [cord blood (CB)] 6 months age relation age, clinical outcomes up 30 months infants with a maternal history atopy. Methods In subset (n = 225) enrolled RCT (ACTRN12606000281594), were assessed peripheral mononuclear cell cytokine responses house dust mite (HDM), ovalbumin (OVA) β-lactoglobulin allergens, or Toll-like receptor (TLR) ligands (lipopolysaccharide, lipoteichoic acid, polyinosinic : polycytidylic acid CpG oligonucleotide) addition (eczema, wheeze allergen sensitisation) age. Results Infants higher (≥ 75 nmol/L, compared < 50 nmol/L) had lower IL-5 IL-13 HDM by (P < 0.001 P = 0.003, respectively). This was also reflected strong inverse correlations between CB (ρ = −0.57; P = 0.0002) (ρ = −0.59, P = 0.0001) responses, similar trend for (ρ = −0.29; P = 0.009) OVA. For innate stimulations, associated greater TLR ligands. Additionally, reduced eczema (P = 0.011) 12 months (P = 0.034). Conclusion This suggests that improving pregnancy infancy may reduce development high-risk inhibiting profiles allergy. Results trials awaited determine efficacy vitamin supplementation allergy prevention.