Macrophage profile in primary versus secondary liver tumors.

摘要: Macrophages are important components of the tumor-associated infiltrate and qualified as one major players cancer-related inflammation. It was shown that tumor cells can either stimulate or mediate apoptosis macrophages (TAMs). To date, there is no general agreement regarding influence TAMs their numbers on progression hepatocellular carcinoma (HCC) hepatic metastases (HM). analyze presence compare in intratumoral (IT) peritumoral (PT) areas with clinical outcome HCC HM patients. Biopsies from 35 39 cases were analyzed. Clinical follow-up data enrolled for each case; colorectal cancer origin 26 identified by immunohistochemistry using anti-CD68 monoclonal antibody. The quantitative assessment performed determining mean number CD68-positive IT PT HM. Two threshold methods applied: 1 (T1) calculated use (-log) Cox method; 2 (T2) considered 1/3 group's mean. For statistical analyses Mann-Whitney U-test, Spearman's correlation, proportional hazard Kaplan-Meier tests applied. 36.12% 27.78% patients alive, median survival 5 17 months HM, respectively (P = 0.05). We found significant two-fold decrease between vs. territories both A positive correlation observed group (rs 0.48, P < 0.05) but not HCC. associated any studied factor. Univariate regression analysis showed stage ≤ II 0.01) increased 0.06, only when T2 value applied) favorable prognosis (HR 2.614 2.457, respectively). multivariate revealed histological grade G2 lobe tumors 0.021 0.045; HR 0.395 0.438, Survival retained impact 0.03), stages 0.007), lobes' 0.007) 0.005) patients' outcome. In low related to cell microenvironment. primary liver better prognosis.