The role of life events and childhood experiences in the development of rheumatoid arthritis.

摘要: OBJECTIVE: To evaluate the role of stressful life events, including negative childhood experiences on development rheumatoid arthritis (RA). METHODS: Retrospective, community based, case-control study founded upon 116 cases, aged 45 to 74 years, registered with Norfolk Arthritis Register (NOAR), who were also participants in European Prospective Investigation Cancer (EPIC). Three controls, matched for age and sex, selected each cases from among EPIC not suffering arthritis. Data adverse during adulthood available a self-report questionnaire. The 1987 American Rheumatism Association (ARA) criteria RA met by 55 NOAR this subset provided primary focus analysis. RESULTS: number timing occurrence as well their subjective immediate impact, did differ between developed controls. Termination pregnancy was only specific event individually associated higher risk developing (OR 3.74; 95% CI 1.4-9.9). Negative RA. However, reported significantly slower adaptation effects events than CONCLUSION: results do support hypothesis that rate exposure or impact play an etiologic