Normal age-dependent values of serum insulin growth factor-I: results from a healthy Italian population.
作者： G. Aimaretti , M. Boschetti , G. Corneli , V. Gasco , D. Valle
DOI: 10.1007/BF03346389
关键词: Sex characteristics 、 Internal medicine 、 Age dependent 、 Percentile 、 Reference values 、 Italian population 、 Serum insulin 、 Endocrinology 、 Medicine 、 Healthy subjects 、 Correlation coefficient 、 Animal science
摘要: Serum IGF-I levels were measured in 547 non-hypopituitaric, non-acromegalic healthy subjects of both sexes Italy to develop reference values relation age and sex. Participant stratified three classes (25- 39, 40-59 >or=60 yr) assay was carried out by double-antibody radio immunoassay. Pearson's correlation coefficient between calculated sex predefined ranges. significantly decreased with (p or=60 yr range. confirmed the negative total sample (r=-0.529). The r did not differ (r=-0.570 males r=-0.529 females), thus reflecting no sex-effect on decline over years. No correlations found 25-39 range (r=-0.036) or (r=-0.080) either, while aged >60 yr, tended further decrease increased (r=0.389). Ranges normal set at 2.5th-97.5th percentile ranges 95.6-366.7 ng/ml 25 39 60.8-297.7 40 59 34.5-219.8 yr. This study may contribute development age-specific for determination serum Italy.
springer.com
elsevier.com
sci-hub.se 参考文章(33)
GH Research Society, None, Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: Summary statement of the GH research society The Journal of Clinical Endocrinology and Metabolism. ,vol. 85, pp. 3990- 3993 ,(2000) , 10.1210/JC.85.11.3990
Breier Bh, Blum Wf, Radioimmunoassays for IGFs and IGFBPs. Growth regulation. ,vol. 4, pp. 11- 19 ,(1994)
Hüsrev Hatemi, Özay Tiryakioglu, Nurhan Ü. Canerolgu, Pinar Kadiolgu, Age dependency of serum insulin - like growth factor (IGF)-1 in healthy Turkish adolescents and adults. Indian Journal of Medical Sciences. ,vol. 57, pp. 543- 548 ,(2003)
Gianluca Aimaretti, Roberto Baldelli, Ginevra Corneli, Chiara Croce,, Silvia Rovere, Claudia Baffoni, Simonetta Bellone, SValentina Gasco, Riccarda Granata, Silvia Grottoli, Ezio Ghigo, IGFs and IGFBPs in adult growth hormone deficiency. Endocrine development. ,vol. 9, pp. 76- 88 ,(2005) , 10.1159/000085758
JEAN-PAUL THISSEN, JEAN-MARIE KETELSLEGERS, LOUIS E. UNDERWOOD, Nutritional Regulation of the Insulin-Like Growth Factors* Endocrine Reviews. ,vol. 15, pp. 80- 101 ,(1994) , 10.1210/EDRV-15-1-80
David R Clemmons, Clinical utility of measurements of insulin-like growth factor 1. Nature Clinical Practice Endocrinology & Metabolism. ,vol. 2, pp. 436- 446 ,(2006) , 10.1038/NCPENDMET0244
Anna-Lena Unden, Stig Elofsson, Sarah Knox, Moira S. Lewitt, Kerstin Brismar, IGF‐I in a normal population: relation to psychosocial factors Clinical Endocrinology. ,vol. 57, pp. 793- 803 ,(2002) , 10.1046/J.1365-2265.2002.01671.X
Fredrik H Nyström, Peter K Öhman, Bertil Å Ekman, Maria K Österlund, Bengt E Karlberg, Hans J Arnqvist, Population-based reference values for IGF-I and IGF-binding protein-1: relations with metabolic and anthropometric variables. European Journal of Endocrinology. ,vol. 136, pp. 165- 172 ,(1997) , 10.1530/EJE.0.1360165
MICHIE KITANO, TAEKO SHIMIZU, YUKO YAMAZAKI, YOSHIE UMEZU, YUKIKO ARAKAWA, YUKAKO DAIMON, Serum insulin-like growth factor-I (IGF-I) in normal Japanese adults. Endocrine Journal. ,vol. 42, pp. 767- 770 ,(1995) , 10.1507/ENDOCRJ.42.767
J. Frystyk, C. Skjærbæk, E. Vestbo, S. Fisker, H. Ørskov, Circulating levels of free insulin-like growth factors in obese subjects: the impact of type 2 diabetes. Diabetes-metabolism Research and Reviews. ,vol. 15, pp. 314- 322 ,(1999) , 10.1002/(SICI)1520-7560(199909/10)15:5<314::AID-DMRR56>3.0.CO;2-E