Neuromyelitis optica and NMO-IgG in European pediatric patients
作者： P. Huppke , M. Bluthner , O. Bauer , W. Stark , K. Reinhardt
DOI: 10.1212/WNL.0B013E3181FC2823
关键词: Pediatrics 、 Cohort study 、 Neuromyelitis optica 、 Pathology 、 Multiple sclerosis 、 Cohort 、 Eye disease 、 El Niño 、 Cranial nerve disease 、 Medicine 、 Central nervous system disease
摘要: Objective: Neuromyelitis optica (NMO) is currently considered a severe relapsing CNS demyelinating disorder that associated with aquaporin-4 immunoglobulin G (NMO-IgG) while in earlier reports of NMO childhood it has been described as benign and monophasic disorder. This study was performed to analyze the prevalence clinical course European pediatric cohort patients disorders. Methods: A evaluating 118 presenting at Center for Multiple Sclerosis Childhood Adolescents, Gottingen, Germany, disorders between 2000 2009. In all patients, NMO-IgG status determined. Results: The majority (94%) were diagnosed remitting recurrent multiple sclerosis. Six fulfilled criteria but only 1 seropositive NMO-IgG. patient had contrast seronegative who showed mild cases course. Conclusions: diagnostic clearly distinguished from other population, very rare not These have predominantly therefore do need immunosuppressant therapy recommended recent literature.
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