Viral aggregation: effects of salts on the aggregation of poliovirus and reovirus at low pH.

摘要: As a first step toward the understanding of virus particle interactions in water, we have used modified single analysis test to follow aggregation poliovirus and reovirus as induced by low pH suspensions containing varying amounts dissolved salts. Salts composed mono-, di-, trivalent cations mono- divalent anions were tested for their ability reduce or increase these viruses relation that obtained alone. Mono- concentrations covering those natural waters generally found cause decrease aggregation, with having much greater effectiveness than monovalent cations. Trivalent ions (Al3+), micromolar concentrations, over at Anions, whether divalent, had little produce inhibition viral thus overall effects due almost exclusively cation. This was true regardless charge on positive negative, determined between isoelectric point which tests carried out. Thus, whereas particles conform classical colloid theory many respects, there are specific exceptions must be taken into account design any experiment is factor.