Interleukin 1: a regulatory role in glucocorticoid-regulated hepatic metabolism.

摘要: The purpose of this study was to investigate the effect interleukin 1 (IL 1) on glucocorticoid-regulated hepatic metabolism. Steroid binding in liver cytosol, plasma glucose, corticosterone, and phosphoenolpyruvate carboxykinase (PEPCK) activity were assayed C3H/HeJ mice after IL administration. Mice received 5 pyrogenic U (PU) rabbit i.p. sacrificed 4 hr later. In adrenal-intact mice, steroid glucose significantly decreased (63 64% control) corticosterone elevated threefold. adrenalectomized (5 PU) treatment produced similar results (66% (71% control). PEPCK measured intact fasted overnight treated with PU 1. induced control animals (23.1 +/- 1.4 U/mg) vs fed (15.9 0.7 U/mg). inhibited induction (13.4 2.0 caused a significant decrease (78% (82% No difference seen 1-treated mice. These data indicate that decreases intracellular receptors, resulting subsequent reduced gluconeogenesis glucose. We propose plays regulatory role