Expression and Clinical Significance of CD147 in Genitourinary Carcinomas
作者： Zhao-dong Han , Hui-chan He , Xue-cheng Bi , Wei-jun Qin , Qi-shan Dai
DOI: 10.1016/J.JSS.2008.11.838
关键词: LNCaP 、 Pathology 、 Metastasis 、 Urinary system 、 Extracellular matrix 、 Carcinoma 、 Biology 、 Immunohistochemistry 、 Immunostaining 、 Genitourinary system
摘要: Background CD147 / extracellular matrix metalloproteinase inducer (EMMPRIN) expressed by tumor cells stimulates peri-tumorous fibroblasts to produce metalloproteinases (MMPs), thus contributing invasion and metastasis. To assess its suitability as a potential therapeutic target, well association with the clinicopathologic features prognosis of patients, expression CD147/EMMPRIN in neoplastic tissues genitourinary system were analyzed. Methods 52 patients renal carcinoma, 58 bladder 101 prostate 17 penis testis carcinoma examined immunostaining on paraffin-embedded specimens using monoclonal antibodies. Then, characteristics patients’ was The RNA interference approach used silence human cell line LNCAP J82. vitro proliferative ability CD147/EMMPRIN-deficient determined 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay. Results tissues, but not normal tissues. Positive shown 42 (80.77%) 41 (70.69%) 67 (66.34%) 16 (94.12%) carcinoma. staining significantly associated TNM stages histological subtypes various urinary carcinomas ( P . Conclusion These results may assist defining target method for predicting poor outcome carcinomas.
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