CD24 expression in urothelial carcinoma of the upper urinary tract correlates with tumour progression
作者： Alexandra Winkler , Richard Zigeuner , Peter Rehak , Georg Hutterer , Thomas Chromecki
DOI: 10.1007/S00428-006-0316-0
关键词: Anatomical pathology 、 Internal medicine 、 Kidney disease 、 Infiltrative Growth Pattern 、 Medicine 、 Transitional cell carcinoma 、 Pathology 、 Tissue microarray 、 CD24 、 Gastroenterology 、 Upper urinary tract 、 Cancer
摘要: Expression of the mucin-like adhesion molecule CD24 has been implicated in progression several types cancer and identified as new prognostic factor. We evaluated expression 268 consecutive cases upper urinary tract urothelial carcinoma with respect to associations tumour stage, grade, angioinvasion infiltrative growth pattern using a tissue microarray technique correlated data patient outcome. was demonstrated 161/259 (62%) evaluable tumours associated high stage [77/139 (55%) pTa/pT1 vs 84/120 (70%) pT2–pT4; P = 0.02] grade [68/139 (49%) low 93/120 (78%) grade; 1 [P < 0.001, risk ratio (RR) 5.87, 95% confidence interval (CI) 2.88–11.95] (P RR 3.30, CI 1.75–6.22) only independent predictors metastatic disease. In conclusion, is advanced well histopathological features indicative aggressive behaviour, but it lacks impact on
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