Clinicopathologic and Prognostic Significance of CD24 in Gallbladder Carcinoma

摘要: CD24, a small cell surface protein, has emerged as novel oncogene and prognostic factor for poor outcomes in many human cancers. However, the association of CD24 expression pattern gallbladder carcinoma with patients' survival not been reported. To shed light on this problem, we performed an analysis relationship between parameters carcinoma. was examined immunohistochemically paraffin-embedded tissue specimens from 207 patients who underwent surgical treatment period January 2004 May 2009. positive found 78.7% (163/207) tumor samples. It tended to be associated positively histological grades pT stages. Kaplan-Meier curves showed that significantly related decreased overall (p < 0.01). Multivariate analysis, including expression, stage, grade, resection margin involvement, independent marker = 0.02; relative risk 1.6). Our data demonstrate first time is important malignancy prognosis Its detection combined cancerous staging may increase ability investigators predict Furthermore, antigen represents attractive target specific therapies monoclonal antibodies CD24-overexpressing carcinoma, so help clinicians select likely benefit molecular therapies.