Reduced N-Myc downstream-regulated gene 2 expression is associated with CD24 upregulation and poor prognosis in patients with lung adenocarcinoma

摘要: N-Myc downstream-regulated gene 2 (NDRG2) has been demonstrated to influence the metastatic potential of hepatocellular carcinoma and breast cancer cells by regulating CD24 expression. The aim this study was investigate roles NDRG2 in clinical pathology lung adenocarcinoma explore whether expression these two markers can be used as independent factors for prediction prognosis patients with tumor. paraffin-embedded specimens gathered from 166 detected immunohistochemical method. correlation proteins clinicopathological parameters statistically analyzed. were highly expressed 59/166 (35.5 %) 110/166 (66.3 patients, respectively. High frequently found tissues early pTNM stage (p = 0.01) without pathological metastasis 0.02), whereas high significantly associated advanced 0.04) 0.01). Univariate analysis indicated that correlated favorable 0.001), opposed 0.001). survival rate NDRG2-low/CD24-high lowest < Multivariate statistical showed conjoined expressions NDRG2-high/CD24-low prognostic indicators 0.03 p 0.02, respectively). Our results suggest decreased or increased is an important feature adenocarcinoma. A combined detection NDRG2/CD24 co-expression may benefit us