Unfavorable prognostic value of CD24 expression in sections from primary and relapsed ovarian cancer tissue.
作者： P. SUROWIAK , V. MATERNA , I. KAPLENKO , M. SPACZYNSKI , M. DIETEL
DOI: 10.1111/J.1525-1438.2006.00555.X
关键词:
摘要: Expression of CD24 represents a poorly recognized, unfavorable prognostic factor. the protein is supposed to facilitate extravasation tumor cells. Our study aimed at examination significance estimation in samples obtained from primary surgeries (PS) and secondary cytoreductions (SCR) (after chemotherapy) ovarian cancer patients. The analyses were performed on sections originating 73 samples. Immunohistochemical reactions paraffin studied tumors, using monoclonal antibodies against CD24. Kaplan–Meier9s analysis showed that significantly shorter overall survival time progression-free was demonstrated characterize cases with cytoplasmic membranous expression (CD24c-m) (P
sci-hub.se 参考文章(10)
T. W. LeBien, Samuel Jay Pirruccello, The human B cell-associated antigen CD24 is a single chain sialoglycoprotein. Journal of Immunology. ,vol. 136, pp. 3779- 3784 ,(1986)
P. Kleihues, B. W. Stewart, World Cancer Report ,(2003)
Glen Kristiansen, Carsten Denkert, Karsten Schlüns, Edgar Dahl, Christian Pilarsky, Steffen Hauptmann, CD24 Is Expressed in Ovarian Cancer and Is a New Independent Prognostic Marker of Patient Survival American Journal of Pathology. ,vol. 161, pp. 1215- 1221 ,(2002) , 10.1016/S0002-9440(10)64398-2
G Kristiansen, K Schlüns, Y Yongwei, C Denkert, M Dietel, I Petersen, CD24 is an independent prognostic marker of survival in nonsmall cell lung cancer patients British Journal of Cancer. ,vol. 88, pp. 231- 236 ,(2003) , 10.1038/SJ.BJC.6600702
Yoshio Shimizu, Seiryu Kamoi, Satoshi Amada, Futoshi Akiyama, Steven G. Silverberg, Toward the development of a universal grading system for ovarian epithelial carcinoma: testing of a proposed system in a series of 461 patients with uniform treatment and follow-up. Cancer. ,vol. 82, pp. 893- 901 ,(1998) , 10.1002/(SICI)1097-0142(19980301)82:5<893::AID-CNCR14>3.0.CO;2-W
Christine H. Holschneider, Jonathan S. Berek, Ovarian cancer: epidemiology, biology, and prognostic factors. Seminars in Surgical Oncology. ,vol. 19, pp. 3- 10 ,(2000) , 10.1002/1098-2388(200007/08)19:1<3::AID-SSU2>3.0.CO;2-S
Glen Kristiansen, Christian Pilarsky, Janja Pervan, Burkhard Stürzebecher, Carsten Stephan, Klaus Jung, Stefan Loening, Andre Rosenthal, Manfred Dietel, CD24 expression is a significant predictor of PSA relapse and poor prognosis in low grade or organ confined prostate cancer The Prostate. ,vol. 58, pp. 183- 192 ,(2004) , 10.1002/PROS.10324
G. Kristiansen, M. Sammar, P. Altevogt, Tumour biological aspects of CD24, a mucin-like adhesion molecule. Journal of Molecular Histology. ,vol. 35, pp. 255- 262 ,(2003) , 10.1023/B:HIJO.0000032357.16261.C5
Joachim Bellach, Peter Altevogt, Klaus-Jürgen Winzer, Christian Pilarsky, Karsten Schlüns, Edgar Dahl, Glen Kristiansen, Empar Mayordomo, Hans Guski, Carsten Denkert, Manfred Dietel, CD24 Expression Is a New Prognostic Marker in Breast Cancer Clinical Cancer Research. ,vol. 9, pp. 4906- 4913 ,(2003)
J. S. Chmiel, W. Hoskins, H. N. Nguyen, H. C. Flessa, K. Zuber, D. P. Winchester, L. H. Karnell, G. Boike, H. E. Averette, National survey of ovarian carcinoma. I. A patient care evaluation study of the American College of Surgeons. Cancer. ,vol. 71, pp. 1629- 1638 ,(1993)