Porphyrin platinum conjugates – new aims
作者： H Brunner , M.R Arndt , B Treittinger
DOI: 10.1016/S0020-1693(03)00479-1
关键词: Photochemistry 、 Conjugate 、 Mammary carcinoma cell line 、 Antitumor activity 、 Medicinal chemistry 、 Molecule 、 Diamine 、 Hematoporphyrin 、 Platinum 、 Porphyrin 、 Chemistry
摘要: Abstract Forty porphyrin platinum conjugates were synthesized, which exhibited a photodynamic effect due to the system and cytostatic fragment present in same molecule. The ligands for complexes synthesized starting from hematoporphyrin deuteroporphyrin. are of (diamine)PtCl 2 , (diamine)Pt(phthalato), (NH 3 ) Pt(dicarboxylato) (diamine)Pt(dicarboxylato) type. Their antitumor activity was tested with MDA-MB-231 mammary carcinoma cell line without irradiation.
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