The Crosstalk between Tissue Engineering and Pharmaceutical Biotechnology: Recent Advances and Future Directions

摘要: Tissue-engineered constructs made of biotechnology-derived materials have been preferred due to their chemical and physical composition, which offers both high versatility a support enclose/ incorporate relevant signaling molecules and/or genes known therapeutically induce tissue repair. Herein, critical overview the impact different materials, scaffolds, recombinant over behavior cells, another element engineered constructs, as well its regulatory role in regeneration disease progression is given. Additionally, these tissue-engineered evolved three-dimensional (3D) tissue-like models that, an advancement two-dimensional standard culture methods, are expected be valuable tool field drug discovery pharmaceutical research. Despite improved design conception current proposed 3D models, advanced control systems enable accelerate streamlining automation numerous labor-intensive steps intrinsic development still achieved. In this sense, review intends present biotechnology- derived that being explored engineering generate tissue-analogues briefly highlight foremost breakthroughs discovery. It also aims reinforce crosstalk between biotechnology has fostering outcomes approaches through use molecules. Gene delivery/therapy discussed forefront area represents cross point biotechnology, nucleic acids can considered "super pharmaceutical" drive biological responses, including regeneration.