Harnessing Investigative Genomics in Heart Failure

摘要: sudden cardiac death (SCD) was a major health problem and constituted an unsolved challenge due to our failure determine its unexplained cause of in teens young adults. Now we know that most those deaths were result heterogeneous genetic heart disorders, either structural cardiomyopathies or arrhythmogenic abnormalities leading (HF). To some extent, developments biology helped delineate functions elements however; the complexity could not be fully grasped. Systems is attempting enable understanding complex conditions such as HF since it can integrate observations stemming from genes their respective products thus allow study cell’s organization physiological behavior [1]. Concomitantly, dramatic change cardiovascular medicine has witnessed sizable reduction patients’ morbidity mortality. However, diseases (CVDs) still remain serious concern globally disappointingly manifestation considerably changed [2]. This shifting landscape presents many challenges opportunities including application investigative genomics along with latest approaches next generation sequencing (NGS) [3]. These options help develop newer tests for diagnosis, prognosis therapeutic interventions monitor both acute coronary injuries chronic diseases. The development should essentially take into account role encoded protein only assess risk CVDs but also treat patients accordingly.