Heart Failure in Congenital Heart Disease: A Confluence of Acquired and Congenital

摘要: Heart failure (HF) is a common cause of morbidity and mortality in congenital heart disease (CHD), with rising prevalence due to improved interventional surgical treatment options outcomes. The interplay between genetic factors acquired postnatal CHD might play major role the progression HF. In this review, we propose three putative routes which lead HF CHD: rare monogenic entities that both HF, severe lesions hemodynamic effects or surgery result most commonly combined effect complex genetics overlapping pathways stressors caused by primary lesion. Novel sequencing technologies have allowed better understanding genomic architecture multiple hypothesized mechanisms through pathway deficiencies led can increase risk Through next-generation drug screening using patient-specific induced pluripotent stem cells, coming years hold tremendous promise confluence yielding effective therapeutics.