Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity
作者： Ping Liang , Feng Lan , Andrew S. Lee , Tingyu Gong , Veronica Sanchez-Freire
DOI: 10.1161/CIRCULATIONAHA.113.001883
关键词:
摘要: Background— Cardiotoxicity is a leading cause for drug attrition during pharmaceutical development and has resulted in numerous preventable patient deaths. Incidents of adverse …
elsevier.com
sci-hub.se 参考文章(59)
R.C. Guy, International Conference on Harmonisation Reference Module in Biomedical Sciences#R##N#Encyclopedia of Toxicology (Third Edition). pp. 1070- 1072 ,(2014) , 10.1016/B978-0-12-386454-3.00861-7
P. M. L. A. van den Bemt, A. C. G. Egberts, A. W. Lenderink, J. M. Verzijl, K. A. Simons, W. S. C. J. M. van der Pol, H. G. M. Leufkens, Adverse drug events in hospitalized patients: A comparison of doctors, nurses and patients as sources of reports European Journal of Clinical Pharmacology. ,vol. 55, pp. 155- 158 ,(1999) , 10.1007/S002280050611
Rashmi R Shah, Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives British Journal of Pharmacology. ,vol. 159, pp. 58- 69 ,(2010) , 10.1111/J.1476-5381.2009.00191.X
Malin K.B. Jonsson, Göran Duker, Charlotte Tropp, Birgit Andersson, Peter Sartipy, Marc A. Vos, Toon A.B. van Veen, Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes. Stem Cell Research. ,vol. 4, pp. 189- 200 ,(2010) , 10.1016/J.SCR.2010.02.001
Dan M. Roden, Mechanisms and management of proarrhythmia American Journal of Cardiology. ,vol. 82, ,(1998) , 10.1016/S0002-9149(98)00472-X
David C Classen, Stanley L Pestotnik, R Scott Evans, James F Lloyd, John P Burke, Adverse Drug Events in Hospitalized PatientsExcess Length of Stay, Extra Costs, and Attributable Mortality JAMA: The Journal of the American Medical Association. ,vol. 277, pp. 301- 306 ,(1997) , 10.1001/JAMA.1997.03540280039031
A. A. Rodriguez-Menchaca, R. A. Navarro-Polanco, T. Ferrer-Villada, J. Rupp, F. B. Sachse, M. Tristani-Firouzi, J. A. Sanchez-Chapula, The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 1364- 1368 ,(2008) , 10.1073/PNAS.0708153105
S.R. Braam, L. Tertoolen, S. Casini, E. Matsa, H.R. Lu, A. Teisman, R. Passier, C. Denning, D.J. Gallacher, R. Towart, C.L. Mummery, Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes Stem Cell Research. ,vol. 10, pp. 48- 56 ,(2013) , 10.1016/J.SCR.2012.08.007
Rashmi R Shah, Drugs, QTc interval prolongation and final ICH E14 guideline. An important milestone with challenges ahead Drug Safety. ,vol. 28, pp. 1009- 1028 ,(2005) , 10.2165/00002018-200528110-00003
Noritaka Yokoo, Shiro Baba, Shinji Kaichi, Akira Niwa, Takahiro Mima, Hiraku Doi, Shinya Yamanaka, Tatsutoshi Nakahata, Toshio Heike, The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells. Biochemical and Biophysical Research Communications. ,vol. 387, pp. 482- 488 ,(2009) , 10.1016/J.BBRC.2009.07.052