Advances in the Study of Heart Development and Disease Using Zebrafish

摘要: Animal models of cardiovascular disease are key players in the translational medicine pipeline used to define conserved genetic and molecular basis disease. Congenital heart diseases (CHDs) most common type human birth defect feature structural abnormalities that arise during cardiac development maturation. The zebrafish, Danio rerio, is a valuable vertebrate model organism, offering advantages over traditional mammalian models. These include rapid, stereotyped external transparent embryos produced large numbers from inexpensively housed adults, vast capacity for manipulation, amenability high-throughput screening. With help modern genetics sequenced genome, zebrafish have led insights ranging CHDs arrhythmia cardiomyopathy. Here, we discuss utility as system summarize morphogenesis with emphasis on parallels diseases. Additionally, specific tools experimental platforms utilized including forward screens, functional characterization candidate genes, high throughput applications.