ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation

作者: Hasem Habelhah , Kavita Shah , Lan Huang , Antje Ostareck-Lederer , A. L. Burlingame

DOI: 10.1038/35060131

关键词: Cellular localizationHeterogeneous-Nuclear Ribonucleoprotein KCell biologyHeterogeneous ribonucleoprotein particleProtein biosynthesisUntranslated regionMolecular biologyMAPK/ERK pathwayBiologyProtein kinase AKinase

摘要: … , or by export of K protein, which is predominantly localized in the nucleus, to the cytoplasm upon phosphorylation by ERK. Although our in vivo phosphorylation data support the latter …

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