Ammonium iodide-promoted cyclization of ketones with DMSO and ammonium acetate for synthesis of substituted pyridines
作者： Xiaojun Pan , Qiao Liu , Liming Chang , Gaoqing Yuan
DOI: 10.1039/C5RA07584J
关键词: Ammonium acetate 、 Organic chemistry 、 Pyridine 、 Ammonium iodide 、 Chemistry
摘要: A simple and efficient method has been developed for the synthesis of symmetrical unsymmetrical pyridines via NH4I-promoted cyclization ketones with DMSO NH4OAc. It was found that methyl always gave selective formation pyridine, while non-methyl unpredictable results (symmetrical or non-symmetrical product only, a mixture two). In addition, deuterium-labeling experiments indicated C4 C6 target pyridine rings resulted from DMSO.
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