Vitamin D and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
作者： Mohamed B. Elamin , Nisrin O. Abu Elnour , Khalid B. Elamin , Mitra M. Fatourechi , Aziz A. Alkatib
DOI: 10.1210/JC.2011-0398
关键词: Endocrinology 、 Context (language use) 、 Myocardial infarction 、 Meta-analysis 、 Vitamin D and neurology 、 Heart disease 、 Internal medicine 、 Confidence interval 、 Randomized controlled trial 、 Relative risk 、 Medicine
摘要: Context: Several studies found association between vitamin D levels and hypertension, coronary artery calcification, heart disease. Objective: The aim of this study was to summarize the evidence on effect cardiovascular outcomes. Design Methods: We searched electronic databases from inception through August 2010 for randomized trials. Reviewers working in duplicate independently extracted characteristics, quality, outcomes interest. Random-effects meta-analysis used pool relative risks (RR) weighted mean differences across Results: 51 eligible trials with moderate quality. Vitamin associated nonsignificant effects patient-important death [RR, 0.96; 95% confidence interval (CI), 0.93, 1.00; P = 0.08], myocardial infarction (RR, 1.02; CI, 1.13; 0.64), stroke 1.05; 0.88, 1.25; 0.59). These analyses were minimal heterogeneity. There no signi...
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endocrine.org 参考文章(74)
RECORD Trial Group, None, Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. The Lancet. ,vol. 365, pp. 1621- 1628 ,(2005) , 10.1016/S0140-6736(05)63013-9
Leon Flicker, Robert J. MacInnis, Mark S. Stein, Sam C. Scherer, Kate E. Mead, Caryl A. Nowson, Jenny Thomas, Chris Lowndes, John L. Hopper, John D. Wark, Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial. Journal of the American Geriatrics Society. ,vol. 53, pp. 1881- 1888 ,(2005) , 10.1111/J.1532-5415.2005.00468.X
Kerry E. Broe, Tai C. Chen, Janice Weinberg, Heike A. Bischoff-Ferrari, Michael F. Holick, Douglas P. Kiel, A Higher Dose of Vitamin D Reduces the Risk of Falls in Nursing Home Residents: A Randomized, Multiple‐Dose Study Journal of the American Geriatrics Society. ,vol. 55, pp. 234- 239 ,(2007) , 10.1111/J.1532-5415.2007.01048.X
O. Grove, B. Halver, Relief of osteoporotic backache with fluoride, calcium, and calciferol. Acta Medica Scandinavica. ,vol. 209, pp. 469- 471 ,(2009) , 10.1111/J.0954-6820.1981.TB11631.X
R M Daly, C A Nowson, Long-term effect of calcium-vitamin D(3) fortified milk on blood pressure and serum lipid concentrations in healthy older men. European Journal of Clinical Nutrition. ,vol. 63, pp. 993- 1000 ,(2009) , 10.1038/EJCN.2008.79
Judith Hsia, Gerardo Heiss, Hong Ren, Matthew Allison, Nancy C Dolan, Philip Greenland, Susan R Heckbert, Karen C Johnson, JoAnn E Manson, Stephen Sidney, Maurizio Trevisan, None, Calcium/Vitamin D Supplementation and Cardiovascular Events Circulation. ,vol. 115, pp. 846- 854 ,(2007) , 10.1161/CIRCULATIONAHA.106.673491
Brian A. Swiglo, M. H. Murad, Holger J. Schünemann, Regina Kunz, Robert A. Vigersky, Gordon H. Guyatt, Victor M. Montori, A case for clarity, consistency, and helpfulness: State-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system The Journal of Clinical Endocrinology and Metabolism. ,vol. 93, pp. 666- 673 ,(2008) , 10.1210/JC.2007-1907
Johan Brohult, Bertil Jonson, Effects of Large Doses of Calciferol on Patients with Rheumatoid Arthritis: A Double-Blind Clinical Trial Scandinavian Journal of Rheumatology. ,vol. 2, pp. 173- 176 ,(1973) , 10.3109/03009747309097085
Marjo Tuppurainen, Anna-Mari Heikkinen, Ilkka Penttilä, Seppo Saarikoski, Does vitamin D3 have negative effects on serum levels of lipids? A follow-up study with a sequential combination of estradiol valerate and cyproterone acetate and/or vitamin D3 Maturitas. ,vol. 22, pp. 55- 61 ,(1995) , 10.1016/0378-5122(95)00909-5
Donna F Stroup, Jesse A Berlin, Sally C Morton, Ingram Olkin, G David Williamson, Drummond Rennie, David Moher, Betsy J Becker, Theresa Ann Sipe, Stephen B Thacker, Meta-analysis of Observational Studies in EpidemiologyA Proposal for Reporting JAMA. ,vol. 283, pp. 2008- 2012 ,(2000) , 10.1001/JAMA.283.15.2008