Early social isolation decreases the expression of calbindin D-28k in rat cerebellar Purkinje cells
作者： Rodrigo Pascual , Enrique Verdú , Antoni Valero , Xavier Navarro
DOI: 10.1016/S0304-3940(99)00608-4
关键词: Endocrinology 、 Calbindin 、 Calbindin d 、 Internal medicine 、 Purkinje neuron 、 Social isolation 、 Calcium 、 Central nervous system 、 Biology 、 Cerebellum 、 General Neuroscience
摘要: The main objective of this study was to analyze the effects early social isolation on expression calbindin D-28k (CAD-28k) in cerebellar Purkinje cells. Sprague-Dawley rats were reared either (IC) or socially housed conditions (SC) from postnatal days 18-32. Half each group sacrificed at 32 age and cerebella processed for immunocytochemical labeling against CAD-28k. remaining IC animals under standard re-socialization between 62. results indicate that cells show a marked loss CAD-28k immunoreactivity, deficiency is recovered by later interaction, although thickness molecular layer remains reduced.
elsevier.com
sci-hub.se 参考文章(21)
H Uno, R Tarara, JG Else, MA Suleman, RM Sapolsky, Hippocampal damage associated with prolonged and fatal stress in primates The Journal of Neuroscience. ,vol. 9, pp. 1705- 1711 ,(1989) , 10.1523/JNEUROSCI.09-05-01705.1989
Anthony M. Iacopino, William B. Rhoten, Sylvia Christakos, Calcium binding protein (calbindin-D28k) gene expression in the developing and aging mouse cerebellum. Molecular Brain Research. ,vol. 8, pp. 283- 290 ,(1990) , 10.1016/0169-328X(90)90041-B
G.H. Jones, T.D. Hernandez, D.A. Kendall, C.A. Marsden, T.W. Robbins, Dopaminergic and serotonergic function following isolation rearing in rats: study of behavioural responses and postmortem and in vivo neurochemistry. Pharmacology, Biochemistry and Behavior. ,vol. 43, pp. 17- 35 ,(1992) , 10.1016/0091-3057(92)90635-S
E.H. Jaffe, V. De Frias, C. Ibarra, Changes in basal and stimulated release of endogenous serotonin from different nuclei of rats subjected to two models of depression Neuroscience Letters. ,vol. 162, pp. 157- 160 ,(1993) , 10.1016/0304-3940(93)90584-8
Kazuma Ojima, Kinzo Matsumoto, Michihisa Tohda, Hiroshi Watanabe, Hyperactivity of central noradrenergic and CRF systems is involved in social isolation-induced decrease in pentobarbital sleep. Brain Research. ,vol. 684, pp. 87- 94 ,(1995) , 10.1016/0006-8993(95)00388-7
Mark P. Mattson, Barbara Rychlik, Ching Chu, Sylvia Christakost, Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-1328k in cultured hippocampal neurons Neuron. ,vol. 6, pp. 41- 51 ,(1991) , 10.1016/0896-6273(91)90120-O
P S Chard, D Bleakman, S Christakos, C S Fullmer, R J Miller, Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neurones. The Journal of Physiology. ,vol. 472, pp. 341- 357 ,(1993) , 10.1113/JPHYSIOL.1993.SP019950
C. Gentsch, M. Lichtsteiner, H. Feer, Individual housing of rats causes divergent changes in spontaneous and reactive activity Experientia. ,vol. 37, pp. 61- 62 ,(1981) , 10.1007/BF01965569
Walter B. Essman, Differences in locomotor activity and brain-serotonin metabolism in differentially housed mice. Journal of Comparative and Physiological Psychology. ,vol. 66, pp. 344- ,(1968) , 10.1037/H0025968
W.A. Anderson, B.A. Flumerfelt, Purkinje cell growth beyond the twenty-third postnatal day Developmental Brain Research. ,vol. 17, pp. 195- 200 ,(1985) , 10.1016/0165-3806(85)90143-9