Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice.
作者： P. Matthew Joyner , Ronni M. Matheke , Lindsey M. Smith , Robert H. Cichewicz
DOI: 10.1021/PR900734G
关键词: Biochemistry 、 Huntingtin 、 Saccharomyces cerevisiae 、 Metabolomics 、 Huntington's disease 、 Yeast 、 Biology 、 Metabolome 、 Mutant 、 Huntingtin Protein
摘要: Metabolomics is a powerful multiparameter tool for evaluating phenotypic traits associated with disease processes. We have used 1H NMR metabolome profiling to characterize metabolic aberrations in yeast model of Huntington’s that are attributable the mutant huntingtin protein’s gain-of-toxic-function effects. A group 11 metabolites (alanine, acetate, galactose, glutamine, glycerol, histidine, proline, succinate, threonine, trehalose, and valine) exhibited significant concentration changes expressing N-terminal fragment human gene. Correspondence analysis was compare results from our data reported transgenic mice gene patients. This technique enabled us identify variety both model-specific (pertaining single species) conserved (observed multiple biomarkers related huntingtin’s toxicity. Among 59 identified, fo...
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