The impact of structural genomics: the first quindecennial

摘要: The period 2000-2015 brought the advent of high-throughput approaches to protein structure determination. With overall funding on order $2 billion (in 2010 dollars), structural genomics (SG) consortia established worldwide have developed pipelines for target selection, production, sample preparation, crystallization, and determination by X-ray crystallography NMR. These efforts resulted in over 13,500 structures, mostly from unique families, increased coverage expanding universe. SG programs contributed 4400 publications scientific literature. NIH-funded Protein Structure Initiatives alone produced 2000 publications, which date attracted more than 93,000 citations. Software database developments that were necessary handle workflows led structures better quality improved integrity associated data. Organized accessible data a positive impact reproducibility experiments. Most experimental generated centers are freely available community has been utilized scientists various fields research. projects created, improved, streamlined, validated many protocols production collection, functional analysis, significantly benefiting biological biomedical