4-benzyl-3-phenyl-5H-furan-2-one, a vasodilator isolated from Malbranchea filamentosa IFM 41300.
作者： Tomoo Hosoe , Toru Iizuka , Shin-ichirou Komai , Daigo Wakana , Takeshi Itabashi
DOI: 10.1016/J.PHYTOCHEM.2005.08.014
关键词: Stereochemistry 、 Aortic rings 、 Vasodilation 、 Spectral analysis 、 Chemical structure 、 Furan 、 Malbranchea filamentosa 、 Vasodilator agents 、 4-benzyl-3-phenyl-5H-furan-2-one 、 Chemistry
摘要: Abstract Screening of Malbranchea filamentosa IFM 41300 for bioactive compounds led to the identification 4-benzyl-3-phenyl-5 H -furan-2-one ( 1 ) as a vasodilator and erythroglaucin 2 ). The structure was established on basis spectroscopic chemical investigations. Compound inhibited Ca 2+ -induced vasocintraction in aortic rings pretreated with high K + (60 mM) or norepinephrine. Finally, compound did not exhibit activity against human pathogenic microorganisms.
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