Phellinone, a new furanone derivative from the Phellinus linteus KT&G PL-2.

作者: Woon Hyung Yeo , Eui Il Hwang , Seung Ho So , Sang Myung Lee

DOI: 10.1007/BF02993957

关键词:

摘要: Phellinone, a new furanone derivative, has been isolated from the stem-cooked rice culture broth ofPhellinus linteus KT&GPL-2. Phellinone was purified by consecutive solvent partition, silica gel, preparative TLC and HPLC. The structure of phellinone assigned as derivative on basis various spectroscopic analyses, including Mass NMR spectroscopies. Its molecular weight formula were found to be 248 C15H20O3, respectively, showed antimicrobial activity againstBacillus subtilis IAM 1090.

参考文章(9)
Eui-Il Hwang, Bong-Sik Yun, Young-Kook Kim, Byoung-Mog Kwon, HONG-GI KIM, Hyang-Bok Lee, Won-Jin Jeong, Sung-Uk Kim, None, Phellinsin A, a novel chitin synthases inhibitor produced by Phellinus sp. PL3. The Journal of Antibiotics. ,vol. 53, pp. 903- 911 ,(2000) , 10.7164/ANTIBIOTICS.53.903
Hwan Mook Kim, Sang Bae Han, Goo Taeg Oh, Young Hee Kim, Dong Ho Hong, Nam Doo Hong, Ick Dong Yoo, Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom phellinus linteus International Journal of Immunopharmacology. ,vol. 18, pp. 295- 303 ,(1996) , 10.1016/0192-0561(96)00028-8
Yun-Hee Shon, Kyung-Soo Nam, Antimutagenicity and induction of anticarcinogenic phase II enzymes by basidiomycetes. Journal of Ethnopharmacology. ,vol. 77, pp. 103- 109 ,(2001) , 10.1016/S0378-8741(01)00276-8
Tomoo Hosoe, Toru Iizuka, Shin-ichirou Komai, Daigo Wakana, Takeshi Itabashi, Koohei Nozawa, Kazutaka Fukushima, Ken-ichi Kawai, 4-benzyl-3-phenyl-5H-furan-2-one, a vasodilator isolated from Malbranchea filamentosa IFM 41300. Phytochemistry. ,vol. 66, pp. 2776- 2779 ,(2005) , 10.1016/J.PHYTOCHEM.2005.08.014
S. Shahapurkar, T. Pandya, N. Kawathekar, S.C. Chaturvedi, Quantitative structure activity relationship studies of diaryl furanones as selective COX-2 inhibitors. European Journal of Medicinal Chemistry. ,vol. 39, pp. 899- 904 ,(2004) , 10.1016/J.EJMECH.2003.12.007
Jong-Ho Cho, Sung-Dae Cho, Hongbo Hu, Sung-Hoon Kim, Song Koo Lee, Yong-Soon Lee, Kyung-Sun Kang, The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide. Carcinogenesis. ,vol. 23, pp. 1163- 1169 ,(2002) , 10.1093/CARCIN/23.7.1163
Hye-Jin Hwang, Sang-Woo Kim, Jang-Won Choi, Jong-Won Yun, Production and characterization of exopolysaccharides from submerged culture of Phellinus linteus KCTC 6190 Enzyme and Microbial Technology. ,vol. 33, pp. 309- 319 ,(2003) , 10.1016/S0141-0229(03)00131-5
Nishikawa Y, Fukuoka F, Shibata S, Nakanishi F, Mei Cf, Antitumor studies on some extracts of Basidiomycetes. GANN Japanese Journal of Cancer Research. ,vol. 59, pp. 159- 161 ,(1968) , 10.20772/CANCERSCI1959.59.2_159
Akito Nagatsu, Shizue Itoh, Rie Tanaka, Setsuko Kato, Mitsumasa Haruna, Keiichi Kishimoto, Hideki Hirayama, Yukihiro Goda, Hajime Mizukami, Yukio Ogihara, Identification of novel substituted fused aromatic compounds, meshimakobnol A and B, from natural Phellinus linteus fruit body Tetrahedron Letters. ,vol. 45, pp. 5931- 5933 ,(2004) , 10.1016/J.TETLET.2004.05.102