Molecular approach to identifying route of transmission of tuberculosis in the community.

摘要: Abstract There is growing concern that tuberculosis spread in Europe the way it USA. We have used DNA "fingerprinting" a systematic evaluation of cases notified our community to uncover foci transmission. An IS6110 probe was test all isolates from culture-confirmed (163 patients) 1991-92 Canton Berne. In total, 45 patients (27 6%), potentially linked on basis restriction fragment length polymorphism, were investigated epidemiologically. The largest group (n=22) included members defined social (drug addicts, homeless persons, alcoholics), whom general population. A key patient developed multidrug-resistant during surveillance period. This population study showed (i) extensive transmission Mycobacterium now taking place same setting as USA; (ii) there definite "spillover" population; (iii) dimensions problem cannot be recognised easily by routine public health service activities because complexity network; and (iv) develops this setting.