CD4 and signal transduction
作者： K. S. Ravichandran , T. L. Collins , S. J. Burakoff
DOI: 10.1007/978-3-642-79798-9_3
关键词: Molecular biology 、 Major histocompatibility complex 、 Endocrinology 、 Antigen 、 Antibody 、 T lymphocyte 、 Glycoprotein 、 In vitro 、 Antigen-presenting cell 、 Biology 、 MHC class II 、 Internal medicine
摘要: Abstract CD4 is a 55–60 kDa monomeric glycoprotein expressed on approximately 60% of peripheral blood T lymphocytes (R einherz et al. 1979; T erhorst et al. 1980). Originally identified as a phenotypic marker (R einherz et al. 1979; W ebb et al. 1979; D ialynas et al. 1983), a role for CD4 in the activation of T lymphocytes was indicated when anti-CD4 antibodies inhibited a variety of T lymphocyte effector functions in vitro (K rensky et al. 1982; S pits et al. 1982; W ilde et al. 1983; R ogozinski et al. 1984). It was later demonstrated that …
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