Mucus of the human olfactory epithelium contains the insulin-like growth factor-I system which is altered in some neurodegenerative diseases.

摘要: Growth factors are believed to be involved in the mitotic regulation of animal olfactory epithelium (OE). We investigated mucus covering human OE area see if it contained insulin-like growth factor-I (IGF-I) and its binding proteins (IGFBPs) examine their behaviour neurodegenerative diseases. Thirty patients with idiopathic late onset cerebellar ataxia (ILOCA), Parkinson's disease, amyotrophic lateral sclerosis (ALS) 30 age- sex-matched healthy subjects were studied. In 10 controls, we also analyzed respiratory mucosa nose tears. detected IGF-I Western ligand blot analysis (WLB) showed IGFBPs an apparent Mr 41,500/38,500, 34,000 24,000, which immunoprecipitated by specific antisera IGFBP-3, -2 -4, respectively. Their levels higher than those observed or Mucus significantly reduced comparison controls. The intensity all IGFBPs-related bands ILOCA, while remaining had a loss amounts IGFBP-3. Plasma similar conclusion, our data show that contains IGFBPs, suggesting these have role activity OE. patients' mucus, possibly reflecting dysfunction itself.