Androstadienone odor thresholds in adolescents

作者: Thomas Hummel , Franziska Krone , Johan N. Lundström , Oliver Bartsch

DOI: 10.1016/J.YHBEH.2004.10.007

关键词: AnosmiaAndrostenoneSexual dimorphismDecreased SensitivityOlfactory systemEndocrinologyAudiologyInternal medicinePsychologyOlfactionOdorAndrostadienone

摘要: A sex-related difference in olfactory sensitivity to androstenone has been reported occur during adolescence. More males than females exhibited anosmia androstenone, or an increase threshold with age. The current study addressed the question whether similar, sexually dimorphic effects of aging over puberty can also be found for androstadienone. total 102 subjects participated (36 females, 66 males). Similar previous investigations, were divided into a group 47 individuals mean age 13.3 years, defined as pre/peri-pubertal, and 55 17.1 post-pubertal. All underwent tests verbal abilities, general function, measurements androstadienone thresholds. provided following major results: (1) Male higher pre/peri-pubertal compared post-pubertal group. This was not observed female subjects. Correspondingly, negative correlation between male subjects, but (2) In contrast this sex-specific change odor threshold, skills identification abilities increased all regardless their sex. conclusion, present observations confirm research on sex-differentiated towards odorous steroids. While underlying causes are unknown, it may hypothesized that decreased could result from endogenous levels Future studies should include both steroid non-steroid odorants futher explore these age-related changes.

参考文章(40)
Thomas V. Getchell, Smell and Taste in Health and Disease ,(1991)
Leslie M. Kay, Gilles Laurent, Odor- and context-dependent modulation of mitral cell activity in behaving rats Nature Neuroscience. ,vol. 2, pp. 1003- 1009 ,(1999) , 10.1038/14801
C.G.D. Brook, Mechanism of puberty. Hormone Research in Paediatrics. ,vol. 51, pp. 52- 54 ,(1999) , 10.1159/000053162
PH Whincup, JA Gilg, K Odoki, SJC Taylor, DG Cook, Age of menarche in contemporary British teenagers: survey of girls born between 1982 and 1986 BMJ. ,vol. 322, pp. 1095- 1096 ,(2001) , 10.1136/BMJ.322.7294.1095
Joel D. Mainland, Elizabeth A. Bremner, Natasha Young, Brad N. Johnson, Rehan M. Khan, Moustafa Bensafi, Noam Sobel, Olfactory plasticity: One nostril knows what the other learns Nature. ,vol. 419, pp. 802- 802 ,(2002) , 10.1038/419802A
John F. Eisenberg, R. T. Doty, Mammalian olfaction, reproductive processes, and behavior. Journal of Wildlife Management. ,vol. 41, pp. 806- ,(1977) , 10.2307/3800018
Melvin M. Grumbach, The neuroendocrinology of human puberty revisited Hormone Research in Paediatrics. ,vol. 57, pp. 2- 14 ,(2002) , 10.1159/000058094
Giovanni Federico, Carlo Maremmani, Luisa Cinquanta, Giampiero Igli Baroncelli, Bruno Fattori, Giuseppe Saggese, Mucus of the human olfactory epithelium contains the insulin-like growth factor-I system which is altered in some neurodegenerative diseases. Brain Research. ,vol. 835, pp. 306- 314 ,(1999) , 10.1016/S0006-8993(99)01614-5