Effects of omalizumab on changes in pulmonary function induced by controlled cat room challenge

摘要: Background Environmental exposure to cat allergen is common, and sensitization allergens strongly associated with asthma. Objective We sought examine the efficacy of omalizumab in preventing acute bronchoconstriction induced by environmental allergen. Methods Patients a history allergen–induced asthma were randomized treatment or placebo exposed controlled chamber for up 1 hour at baseline after 16 weeks treatment. The primary outcome was area under curve percentage decrease from prechallenge FEV week omalizumab-treated versus placebo-treated patients. recorded before every 10 minutes during 1-hour challenge. Chest, nasal, ocular symptoms also monitored as secondary end points. Results 15.2% per patients (n = 32) 27.3% (n = 33), reflecting 44% less reduction difference −12.1% ( P  = .0009; 95% CI, −19.0 −5.2). Compared patients, able tolerate longer .0006) demonstrated significant reductions values their chest symptom score  = .0002). Conclusions severity airway reactions caused room significantly reduced omalizumab.