HYPOXIA-INDUCED BRONCHIAL RESPONSIVENESS IN AWAKE SHEEP : ROLE OF CAROTID CHEMORECEPTORS

摘要: Hypoxia enhances bronchial responsiveness in sheep and dogs we recently reported a similar effect asthmatic subjects. Activation of reflex arc due to stimulation peripheral chemoreceptors has been suggested explain this finding. We evaluated the contribution carotid body hypoxia-induced conscious sheep. Incremental concentrations aerosolized methacholine were given each seven ventilated successively (in random order) with normoxic hypoxic gas mixture (15% O2 N2), both before after surgical chemodenervation. alone did not affect lung mechanics intact or chemodenervated animals. Bronchial was significantly increased by hypoxia sheep, as compared conclude that stimulating on awake seen human patients asthma. This may be mediated chemoreceptors, which turn influence nervous control airway calibre.