Fluctuations in Cytosolic Calcium Regulate the Neuronal Malate–Aspartate NADH Shuttle: Implications for Neuronal Energy Metabolism

摘要: The malate-aspartate NADH shuttle (MAS) operates in neurons and other cells to translocate reducing equivalents from the cytosol mitochondrial matrix, thus allowing a continued flux through glycolytic pathway metabolism of extracellular lactate. Recent discoveries have taught us that MAS is regulated by fluctuations cytosolic Ca(2+) levels, this regulation required maintain tight coupling between neuronal activity respiration oxidative phosphorylation. At below threshold calcium uniporter, there positive correlation activity; however, if increases above threshold, thought be reduced an intricate mechanism. latter forces partly rely on anaerobic glycolysis producing lactate may metabolized subsequently, or cells. In review, we will discuss evidence for Ca(2+)-mediated been uncovered over last decade so, together with need further verification, examine metabolic ramifications neurons.