G Protein-Coupled Receptor 87: a Promising Opportunity for Cancer Drug Discovery.

摘要: G protein-coupled receptors (GPRs) constitute one of the largest families membrane proteins encoded by human genome. Upon binding to various ligands, these seven-transmembrane play an essential role in many physiological processes, including neurotransmission, immunity, inflammation, regulation mood and behavior. In view their important functions, aberrant expression activity GPRs have been implicated a wide spectrum diseases, tumorigenesis. GPR87, cell surface GPR related LPA receptor family, is overexpressed diverse carcinomas plays tumor survival. our recent work, we uncovered that GPR87 regulated suppressor p53 DNA damage p53-dependent manner. Moreover, found lack triggers increase p53, concomitant with decrease Akt, which results sensitization cells damage-induced apoptosis growth suppression. Altogether, function for survival response stress signals. Due unique structure, localization ligand ability, extensively used drug development are most common targets commercial drugs. Although studies required determine natural ligand(s) signaling pathways, undoubtedly very promising novel target cancer prevention treatment.