The p53 pathway: positive and negative feedback loops
作者： Sandra L Harris , Arnold J Levine
关键词: Cell cycle 、 Cell biology 、 Positive feedback 、 Biology 、 Cell division 、 Genetics 、 Signal transduction 、 Ubiquitin 、 Negative feedback 、 Transcription factor 、 Mitogen-activated protein kinase
摘要: The p53 pathway responds to stresses that can disrupt the fidelity of DNA replication and cell division. A stress signal is transmitted protein by post-translational modifications. This results in activation as a transcription factor initiates program cycle arrest, cellular senescence or apoptosis. transcriptional network p53-responsive genes produces proteins interact with large number other transduction pathways positive negative autoregulatory feedback loops act upon response. There are at least seven three described here, these, six through MDM-2 regulate activity. circuit communicates Wnt-beta-catenin, IGF-1-AKT, Rb-E2F, p38 MAP kinase, cyclin-cdk, p14/19 ARF cyclin G-PP2A, p73 gene products. different ubiquitin ligases an manner: MDM-2, Cop-1 Pirh-2. meaning this redundancy relative activity each these types stages development remains be elucidated. interconnections between will play central role our understanding cancer.
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