Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
作者： Paul H. Kussie , Svetlana Gorina , Vincent Marechal , Brian Elenbaas , Jacque Moreau
DOI: 10.1126/SCIENCE.274.5289.948
关键词:
摘要: The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind the transactivation domain of p53 and downregulate its ability to activate transcription. In certain cancers, MDM2 amplification is a common event and contributes to the inactivation of p53. The crystal structure of the 109-residue amino-terminal domain of MDM2 bound to a 15-residue transactivation domain peptide of p53 revealed that MDM2 has a deep hydrophobic cleft on which the p53 peptide binds as an amphipathic α helix. The interface relies on the …
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