NIR analysis of cellulose and lactose—Application to ecstasy tablet analysis

摘要: Cellulose and lactose are the most frequently used excipients in illicit ecstasy production. The aim of this project was to use near infrared reflectance spectroscopy (NIRS) for determination different chemical forms these two substances, as well differentiation their origin (producer). It possible distinguish between both compounds, origins (producers), although within limits. Furthermore, possibilities apply NIR analysis substances such found tablets were studied. First, a few cellulose samples chosen make mixtures with amphetamine at three degrees purity (5, 10 15%), order study resulting changes spectra simultaneously quantify identify excipient. A PLS2 model could be build predict concentrations Secondarily, technique applied real tablets. About 40 seizures analysed determine excipient check them against each other. Identification not always obvious, especially when more than one present. However, comparison appeared give groups similar samples. results representing tablet blend whole taking into account all absorbing compounds. Although NIRS seems an appropriate method profiling, little is known about intra- intervariability compression batches.