Nanotubes in the human respiratory tract – Deposition modeling

摘要: Deposition of inhaled single-wall carbon nanotubes (SWCNT) and multi-wall (MWCNT) in the respiratory tract was theoretically investigated for various age groups (infants, children, adolescents, adults). Additionally, possible effects inhalative flow rate on nanotube deposition were simulated adult lungs. Theoretical computations based aerodynamic diameter concept assumption particles being randomly transported through a stochastic (close-to-realistic) lung structure. calculated by application well validated empirical formulae, thereby considering Browian motion, inertial impaction, interception, sedimentation as main mechanisms acting particles. Results simulations clearly show that given inhalation scenario (sitting breathing) total, bronchial, acinar increase with subject's age, whereas extrathoracic is characterized decrease from younger to older subjects. According data provided model, MWCNT, whose diameters exceed those SWCNT one order magnitude, are deposited specific compartments lower extent than SWCNT. A change physical state sitting heavy work results common decline bronchial nanotubes. Total slightly increased moderately decreased significantly MWCNT. Based this contribution it may be concluded bear higher potential health hazards because they accumulated sensitive regions doses